Publications
2025
- Wu, H., Lee, C.H., Abiri, N., and Ionita-Laza, I. Domain-aware matrix completion for phenotype prediction from Electronic Health Record data with applications to genomic analyses. (Under Review).
- Luo, Y. et al. Cross-Phenotype Genome-Wide Association Study on the Shared Genetic Susceptibility to Systemic Sclerosis and Primary Biliary Cholangitis. Arthritis Rheumatol 77, 727–739 (2025).
- Lee, C.H., Khan, A., Weng, C., Buxbaum, J.D., Kiryluk, K., and Ionita-Laza, I. Liability threshold model-based disease risk prediction based on Electronic Health Record phenotypes. Nature Genetics (2025).
- Lee, C.H. Pleiotropy in Multitrait Genome-Wide Association Studies: Approaches and Insights From Schizophrenia–Cognition Analyses. Biological Psychiatry 98, 650–651 (2025).
2023
- Jung, S., Lee, C.H., Sul, J.H. & Han, B. Building an optimal predictive model for imputing tissue-specific gene expression by combining genotype and whole-blood transcriptome data. HGG Adv 4, 100223 (2023).
2018
- Kang, E.Y. et al. An Association Mapping Framework To Account for Potential Sex Difference in Genetic Architectures. Genetics 209, 685–698 (2018).
- Han, B. et al. Amino acid position 37 of HLA-DRβ1 affects susceptibility to Crohn's disease in Asians. Hum Mol Genet 27, 3901–3910 (2018).
2017
- Lee, C.H., Eskin, E. & Han, B. Increasing the power of meta-analysis of genome-wide association studies to detect heterogeneous effects. Bioinformatics 33, i379–i388 (2017).
- Kim, E.E. et al. FOLD: a method to optimize power in meta-analysis of genetic association studies with overlapping subjects. Bioinformatics 33, 3947–3954 (2017).
2016
- Lee, C.H., Cook, S., Lee, J.S. & Han, B. Comparison of Two Meta-Analysis Methods: Inverse-Variance-Weighted Average and Weighted Sum of Z-Scores. Genomics Inform 14, 173–180 (2016).
- van ’t Hof, F.N. et al. Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms. J Am Heart Assoc 5 (2016).
- Network, N.S.G. & International Stroke Genetics, C. Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study. Lancet Neurol 15, 174–184 (2016).
- Jung, J. et al. Generation and molecular characterization of pancreatic cancer patient-derived xenografts reveals their heterologous nature. Oncotarget 7, 62533–62546 (2016).
- Han, B. et al. A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases. Nat Genet 48, 803–810 (2016).
2015
- Kwak, S.H. et al. Association of HLA Genotype and Fulminant Type 1 Diabetes in Koreans. Genomics Inform 13, 126–131 (2015).
2021
- Lee, C.H., Shi, H., Pasaniuc, B., Eskin, E. & Han, B. PLEIO: a method to map and interpret pleiotropic loci with GWAS summary statistics. American Journal of Human Genetics 108, 36–48 (2021).
Fellowship and Grant Support
Current
- 09/2024 – 09/2029 NHGRI (K99/R00) 1K99HG013546 — New York, NY
Past
- 02/2019 – 02/2021 Graduate School Scholarship in Biomedical Sciences, Asan Foundation ($20,000/yr) — Seoul, S. Korea
Conference Presentations – Peer-Selected (International)
- Lee, C.H., Wu, H., Abiri, N., & Ionita-Laza, I. “covImpute: Leveraging Genetic Correlations to Impute Missing EHR Phenotypes.” International Genetic Epidemiology Society, Cologne, Germany, September 2025.
- Lee, C.H., Eskin, E., & Han, B. “Increasing the Power of Meta-Analysis of Genome-Wide Association Studies to Detect Heterogeneous Effects.” ISMB/ECCB, Prague, Czech Republic, July 2017.
Invited Presentations – Regional and National
- Lee, C.H. “Medical Record-Based Disease Risk Prediction Model (LTPI)” Academic Seminar hosted by Biological Research Information Center (BRIC), Pohang University of Science and Technology, South Korea, January 2026.
- Lee, C.H. “Liability threshold model-based disease risk prediction based on electronic health record phenotypes” Division of Epidemiology, Vanderbilt University, December 2025.
- Lee, C.H. “Harnessing Pleiotropic Signals to Transform Precision Medicine.” Cancer Control and Population Science Program Meeting, Comprehensive Cancer Center, University of New Mexico, February 2025.
- Lee, C.H. “My Journey to K99: Research Strategy and Innovation Social Lunch.” Office of the Vice Dean for Research Strategy, Columbia University, March 2025.